PDZRN3 destabilizes endothelial cell-cell junctions through a PKCzeta-containing polarity complex to increase vascular permeability

Endothelial cells serve as a barrier between blood and tissues. Maintenance of the endothelial cell barrier depends on the integrity of intercellular junctions, which is regulated by a polarity complex that includes the zeta isoform of atypical protein kinase C...
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Expressed by Endothelial Cells Controls Blood Vessel Formation Through Wnt/β-Catenin Canonical Signaling.

Abstract OBJECTIVE: Vessel formation requires precise orchestration of a series of morphometric and molecular events controlled by a multitude of angiogenic factors and morphogens. Wnt/frizzled signaling is required for proper vascular formation. In this study, we...
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Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway.

Abstract Angiogenesis involves the coordinated growth and migration of endothelial cells (ECs) toward a proangiogenic signal. The Wnt planar cell polarity (PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morphogenesis...
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Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes.

Abstract AIMS: Microangiopathy, i.e. endothelial dysfunction, has long been suggested to contribute to the development of diabetic neuropathy, although this has never been fully verified. In the present paper, we have identified the role of Hedgehog (Hh) signalling in...
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Intrinsically impaired platelet production in some patients with persistent or chronic immune thrombocytopenia

Persistent or chronic immune thrombocytopenias (P/C-ITP) are acquired blood disorders lasting more than 3 months or 1 year, respectively. The pathogenesis of these disorders is thought to be immunological. We hypothesized that some patients with P/C-ITP might have an...
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The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling

Development and stabilization of a vascular plexus requires the coordination of multiple signalling processes. Wnt planar cell polarity (PCP) signalling is critical in vertebrates for diverse morphogenesis events, which coordinate cell orientation within a...
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Frizzled7 controls vascular permeability throughthe Wnt-canonical pathway and cross-talk with endothelial cell junction complexes

AIMS: Vascular permeability is essential for the health of normal tissues and is an important characteristic of many disease states. The role of the Wnt/frizzled pathway in vascular biology has recently been reported. The objectives of this study are to analyse the...
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Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation

Recruitment of mural cells (MCs), namely pericytes and smooth muscle cells (SMCs), is essential to improve the maturation of newly formed vessels. Sonic hedgehog (Shh) has been suggested to promote the formation of larger and more muscularized vessels, but the...
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Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice.

OBJECTIVE: The purpose of this study is to further document alteration of signal transduction pathways, more particularly of hedgehog (Hh) signaling, causing impaired ischemic muscle repair in old mice. APPROACH AND RESULTS: We used 12-week-old (young mice) and 20- to...
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Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis

RATIONALE: A better understanding of the mechanism underlying skeletal muscle repair is required to develop therapies that promote tissue regeneration in adults. Hedgehog signaling has been shown previously to be involved in myogenesis and angiogenesis: 2 crucial...
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Selected 2017-2011 basic research publications


Pdzrn3 destabilizes endothelial cell-cell junctions through a pkczeta-containing polarity complex to increase vascular permeability. Sci Signal. 2017;10

Sewduth RN, Kovacic H, Jaspard-Vinassa B, Jecko V, Wavasseur T, Fritsch N, Pernot M, Jeaningros S, Roux E, Dufourcq P, Couffinhal T, Duplaa C.

  • Pillois X, Nurden A. Linkage disequilibrium amongst itga2b and itgb3 gene variants in patients with glanzmann thrombasthenia confirms that most disease-causing mutations are recent. Br J Haematol. 2016:686-695

  • Peghaire C, Bats ML, Sewduth RN, Jeanningros S, Jaspard B, Couffinhal T, Duplaa C, Dufourcq P. Fzd7 (frizzled-7) expressed by endothelial cells controls blood vessel formation through wnt/β-catenin canonical signaling. Arterioscler Thromb Vasc Biol. 2016:2369-2380

  • Merched A, Daret D, Li L, Franzl N, Sauvage-Merched M. Specific autoantigens in experimental autoimmunity-associated atherosclerosis. Faseb J. 2016

  • Guillabert-Gourgues A, Jaspard B, Bats ML, Sewduth RN, Franzl N, Peghaire C, Jeanningros S, Moreau C, Roux E, Larrieu Laharque F, Dufourcq P, Couffinhal T, Duplaa C. Kif26b controls endothelial cell polarity through the dishevelled/daam1-dependent planar cell polarity-signaling pathway. Mol Biol Cell. 2016:941-953

  • Fiore M, Goulas C, Pillois X. A new mutation in tubb1 associated with thrombocytopenia confirms that c-terminal part of β1-tubulin plays a role in microtubule assembly. Clin Genet. 2016

  • Chapouly C, Yao Q, Vandierdonck S, Larrieu Laharque F, Mariani JN, Gadeau A, Renault MA. Impaired hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: Implication in diabetes. Cardiovasc Res. 2016:217-227.

  • Wehbe K, Forfar I, Eimer S, Cinque G. Discrimination between two different grades of human glioma based on blood vessel infrared spectral imaging. Anal Bioanal Chem. 2015;407(24):7295-7305

  • Riviere E, Viallard JF, Guy A, Kilani B, Vieira-Dias J, Pons AC, Couffinhal T, Pellegrin JL, James C. Intrinsically impaired platelet production in some patients with persistent or chronic immune thrombocytopenia. Brit J Haematol. 2015

  • Riviere E, Saint-Lezer A, James C, Delmas Y, Clouzeau B, Bui N, Vital A, Coppo P, Gruson D, Boyer A. Platelet transfusion and catheter insertion for plasma exchange in patients with thrombotic thrombocytopenic purpura and a low platelet count. Transfusion. 2015;55(7):1798-1802

  • Mohamed IA, Gadeau A, Fliegel L, Lopaschuck G, Mlih M, Abdulrahman N, Fillmore N, Mraiche F. Na+/h+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy. PLoS One. 2015;10(4):e0123318.

  • Mlih M, Abdulrahman N, Gadeau AP, Mohamed IA, Jaballah M, Mraiche F. Na(+)/h (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves nfat3/gata4. Molecular and cellular biochemistry. 2015;404:211-220

  • Chapouly C, Yao Q, Vandierdonck S, larrieu-Lahargue F, Mariani JN, Gadeau A, Renault MA. Impaired hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy. Implication in diabete. Cardiovasc Res. 2015

  • Yao Q, Renault MA, Chapouly C, Vandierdonck S, Belloc I, Jaspard-Vinassa B, daniel Lamazière JM, Laffargue M, Merched A, desgranges C, Gadeau AP. Sonic hedgehog mediates a novel pathway of pdgf-bb-dependent vessel maturation. Blood. 2014;123:2429-2437

  • Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudouneche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M. Targeting pi3kgamma activity decreases vascular trauma-induced intimal hyperplasia through modulation of the th1 response. The Journal of experimental medicine. 2014;211:1779-1792

  • Sewduth RN, Jaspard B, Peghaire C, Guillabert-Gourgues A, Franzl N, Larrieu-Lahargue F, Moreau C, Fruttiger M, Dufourcq P, Couffinhal T, Duplaa C. The ubiquitin ligase pdzrn3 is required for vascular morphogenesis through wnt/planar cell polarity signalling. Nat Commun. 2014;5:4832

  • Ferreira Tojais N, Peghaire C, Franzl N, Larrieu-Lahargue F, Jaspard B, Reynaud A, Moreau C, Couffinhal T, Duplaa C, Dufourcq P. Frizzled7 controls vascular permeability throughthe wnt-canonical pathway and cross-talk with endothelial cell junction complexes. Cardiovasc Res. 2014;103:291-303

  • Dalal S, Zha Q, Daniels C, Steagall R, Joyner W, Gadeau AP, Singh M, Singh K. Ostéopontin stimulates apoptosis in adult cardiac myocytes via the involvement of cd44 receptors, mitochondrial death pathway and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol. 2014;306:1182-1191

  • Martin-Latry K, Cazaux J, Lafitte M, Couffinhal T. Negative impact of physician precribed drug dosing schedule requirements on patient adherence to cardiovascular drugs. Pharmacoepidemiol Drug Saf. 2014

  • Renault MA, Vandierdonck S, Chapouly C, Yu Y, Qin G, Metras A, Couffinhal T, Losordo DW, Yao Q, Reynaud A, Jaspard-Vinassa B, Belloc I, Desgranges C, Gadeau AP. Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis. Circ Res. 2013;113:1148-1158

  • Renault MA, Robbesyn F, Chapouly C, Yao Q, Vandierdonck S, Reynaud A, Belloc I, Traiffort E, Ruat M, Desgranges C, Gadeau AP. Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice. Arterioscler Thromb Vasc Biol. 2013;33:2858-2866

  • Renault MA, Chapouly C, Yao Q, Larrieu-Lahargue F, Vandierdonck S, Reynaud A, Petit M, Jaspard-Vinassa B, Belloc I, Traiffort E, Ruat M, Duplaa C, Couffinhal T, Desgranges C, Gadeau AP. Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. Circ Res. 2013;112:762-770

  • Pillois X, Fiore M, Heilig R, Pico M, Nurden A. A novel amino acid substitution of integrin αiib in glanzmann thrombasthenia confirms that the n-terminal region of the receptor plays a role in maintaining β-propeller structure. Platelets. 2013;24:77-80

  • Nurden A, Pillois X, Wilcox DA. Glanzmann thrombasthenia: State of the art and future directions. Semin Thromb Hemost. 2013;39:642-655

  • Merched A. A breakthrough towards preventing cardiovascular diseases. European Commission. 2013

  • Mathus V, Valenzuela G, Saez CG, Hidalgo P, Lagos M, Aranda E, Panes E, Pereira J, Pillois X, Nurden A, Mezzano D. An adenine insertion in exon 6 of human gp6 generates a truncated protein associated with a bleeding disorder in four chilean families. J Thromb Haemost. 2013;11:1751-1759

  • Laguerre M, Sabi E, Daly J, Stochley P, Nurden P, Pillois X, Nurden A. Molecular dynamics analysis of a novel β3 pro189ser mutation in a patient with glanzmann thrombasthenia differentially affecting αiibβ3 and αvβ3 expression. PLoS One. 2013;8:e78683

  • Jujo K, Li M, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault MA, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, Losordo D. Cxc-chemokine receptor 4 antagonist amd3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism. Circulation. 2013;127:63-73

  • Jaussaud J, Biais M, Calderon J, Chevaleyre J, Duchez P, Ivanovic Z, Couffinhal T, Barandon L. Hypoxia-preconditioned mesenchymal stromal cells improve cardiac function in a swine model of chronic myocardial ischaemia. Eur J Cardiothorac Surg. 2013;43:1050-1057

  • Girodet PO, Ozier A, Carvalho G, Llina O, Ousova O, Gadeau AP, Begueret H, Wulff H, Marthan R, Bradding P, Berger P. Ca(2+)-actived k(+) channel-3.1 blocker tram-34 attenuates airway remodeling and eosinophilia in a murine asthma model. Am J Respir Cell Mol Biol. 2013;48:212-219

  • Dubois M, Delannoy E, Duluc L, Closs E, Li H, Toussaint C, Gadeau AP, Gödecke A, Freund-Michel V, Courtois A, Marthan R, Savineau JP, Muller B. Biopterin metabolism and enos expression during hypoxic pulmonary hypertension in mice. PLoS One. 2013;8:eCollection 2013

  • Biais M, Calderon J, Pernot M, Barandon L, Couffinhal T, Ouattara A, Sztark F. Predicting fluid responsiveness during infrarenal aortic cross-clamping in pigs. J Cardiothorac Vasc Anesth. 2013;27:1101-1107

  • Sekiguchi H, Li M, Jujo K, Renault MA, Thorne T, Clarke T, Ito A, Tanaka T, Klyachko E, Tabata Y, Hagiwara N, Losordo D. Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein. Lab Invest. 2012;92:532-542

  • Pillois X, Gautier T, Bouillet B, Pais de Barros JP, Jeannin A, Verges B, Bonnet J, Lagrost L. Constitutive inhibition of plasma cetp by apolipoprotein c1 is blunted in dyslipidemic patients with coronary artery disease. J Lipid Res. 2012;53:1200-1209

  • Nishimura Y, Li M, Qin G, Hamada H, Asai J, Takenaka H, Sekiguchi H, Renault MA, Jujo K, Katoh N, Kishimoto S, Ito A, Kamice C, Kenny J, Millay M, Misener S, Thorne T, Losordo D. Cxcr4 antagonist amd3100 accelerates impaired wound healing in diabetic mice. J Invest Dermatol. 2012;132:711-720

  • Latry P, Martin-Latry K, Lafitte M, Peter C, Couffinhal T. Dual antiplatelet therapy after myocardial infarction and percutaneous coronary intervention: Analysis of patient adherence using a french health insurance reimbursement database. Eurointervention. 2012;7:1413-1419

  • Gadeau AP, Arnal JF. Estrogen-related receptor-y: Conductor of muscle angiogenesis through conversion of fast- to slow-twitch fiber? Circ Res. 2012;110:1042-1044

  • Fiore M, Firah N, Pillois X, Nurden P, Heilig R, Nurden A. Natural history of platelet antibody formation against αiibβ3 in a french cohort of glanzmann thrombasthenia patients. Haemophilia. 2012;18:201-209

  • Descamps B, Sewduth RN, Ferreira Tojais N, Jaspard-Vinassa B, Reynaud A, Sohet F, Lacolley P, Allières C, Lamaziere JM, Moreau C, Dufourcq P, Couffinhal T, Duplaa C. Frizzled 4 regulates arterial network organization through noncanonical wnt/planar cell polarity signaling. Circ Res. 2012;110:47-58

  • Vigneron F, Dos Santos P, Lemoine S, Bonnet M, Tariosse L, Couffinhal T, Duplaa C, Jaspard-Vinassa B. Gsk-3beta at the crossroads in the signalling of heart preconditioning: Implication of mtor and wnt pathways. Cardiovasc Res. 2011;90:49-56

  • Saks V, Kuznetsov AV, Gonzalez-Granillo M, Tepp K, Timohhina N, Karu-Varikmaa M, Kaambre T, Dos Santos P, Boucher F, Guzun R. Intracellular energetic units regulate metabolim in cardiac cells. J Mol Cell Cardiol. 2011;52 (2012):419-436

  • Roncalli J, Renault MA, Tongers J, Misener S, Thorne T, Kamide C, Jujo K, Tanaka T, Ii M, Klyachko E, Losordo DW. Sonic hedgehog-induced functional recovery after myocardial infarction is enhanced by amd3100-mediated progenitor-cell mobilization. J Am Coll Cardiol. 2011;57:2444-2452

  • Ray R, Murdoch CE, Wang M, Santos CX, Zhang M, Alom-Ruiz S, Anilkumar N, Ouattara A, Cave AC, Walker SJ, Grieve DJ, Charles RL, Eaton P, Brewer AC, Shah AM. Endothelial nox4 nadph oxidase enhances vasodilatation and reduces blood pressure in vivo. Arterioscler Thromb Vasc Biol. 2011;31:1368-1376

  • Nurden P, Youlouz-Marfak I, Siberchicot F, Kostrzewa E, Andia I, Anitua E, Nurden AT. Use of autologous platelet-rich clots for the prevention of local injury bleeding in patients with severe inherited mucocutaneous bleeding disorders. Haemophilia. 2011;17:620-624

  • Nurden AT, Fiore M, Nurden P, Pillois X. Glanzmann thrombasthenia: A review of itga2b and itgb3 defects with emphasis on variants, phenotypic variability, and mouse models. Blood. 2011

  • Nurden AT, Fiore M, Nurden P, Heilig R, Pillois X. Are bone defects in rare patients with glanzmann’s thrombasthenia associated with itgb3 or itga2b mutations? Platelets. 2011

  • Nurden A, Pillois X, Fiore M, Heilig R, Nurden P. Glanzmann thrombasthenia-like syndromes associated with macrothrombocytopenias and mutations in the genes encoding the αiibβ3 integrin. Semin Thromb Hemost. 2011;37:698-706

  • Nurden A, Nurden P. Advances in our understanding of the molecular basis of disorders of platelet function. J Thromb Haemost. 2011;9 Suppl 1:76-91

  • Navarro-Nunez L, Teruel R, Anton AI, Nurden P, Martinez-Martinez I, Lozano ML, Rivera J, Corral J, Mezzano D, Vicente V, Martinez C. Rare homozygous status of p43 beta1-tubulin polymorphism causes alterations in platelet ultrastructure. Thromb Haemost. 2011;105:855-863

  • Merched A, Chan L. Nutrigenetics and nutrigenomics of atherosclerosis. Current Atherosclerosis Reports. 2011;15:328

  • Merched A. Inflammation in chronic and infectious diseases. Clin Chim Acta. 2011;10.1016/j.cca.2011.10.006

  • Mbikou P, Fajmut A, Brumen M, Roux E. Contribution of rho kinase to the early phase of the calcium-contraction coupling in airway smooth muscle. Exp Physiol. 2011;96:240-258

  • Latry P, Molimard M, Dedieu B, Couffinhal T, Begaud B, Martin-Latry K. Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: A cohort study. BMC Cardiovasc Disord. 2011;11:46

  • Latry P, Martin-Latry K, Labat A, Molimard M, Peter C. Use of principal component analysis in the evaluation of adherence to statin treatment: A method to determine a potential target population for public health intervention. Fundam Clin Pharmacol. 2011;25:528-533

  • Latry P, Lafitte M, Peter C, Couffinhal T, Martin-Latry K. Dual antiplatelet therapy after myocardial infarction and percutaneous coronary intervention: Analysis of patient adherence using health reimbursement database. European Society for Patient Adherence, COmpliance and Persistence (ESPACOMP). 2011

  • Galvin A, Lafitte M, Couffinhal T, Martin-Latry K. Medication adherence scale available in chronic disorders: A literature review. European Society for Patient Adherence, COmpliance and Persistence (ESPACOMP). 2011

  • Fiore M, Pillois X, Nurden P, Nurden AT, Austerlitz F. Founder effect and estimation of the age of the french gypsy mutation associated with glanzmann thrombasthenia in manouche families. Eur J Hum Genet. 2011;19:981-987

  • Khellaf M, Michel M, Quittet P, Viallard JF, Alexis M, Roudot-Thoraval F, Cheze S, Durand JM, Lefrere F, Galicier L, Lambotte O, Panelatti G, Slama B, Damaj G, Sebahoun G, Gyan E, Delbrel X, Dhedin N, Royer B, Schleinitz N, Rossi JF, Mahevas M, Languille L, Bierling P, Godeau B. Romiplostim safety and efficacy for immune thrombocytopenia in clinical practice: 2-year results of 72 adults in a romiplostim compassionate-use program. Blood. 2011

  • Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF. Activation function 2 (af2) of estrogen receptor-α is required for the atheroprotective action of estradiol but not to accelerate endothelial healing. Proc Natl Acad Sci U S A. 2011;108:13311-13316

  • Bartsch I, Sandrock K, Lanza F, Nurden P, Hainmann I, Pavlova A, Greinacher A, Tacke U, Barth M, Busse A, Oldenburg J, Bommer M, Strahm B, Superti-Furga A, Zieger B. Deletion of human gp1bb and sept5 is associated with bernard-soulier syndrome, platelet secretion defect, polymicrogyria, and developmental delay. Thromb Haemost. 2011;106:475-483

  • Barandon L, Casassus F, Leroux L, Moreau C, Allieres C, Lamaziere JM, Dufourcq P, Couffinhal T, Duplaa C. Sfrp-1 improves postinfarction scar formation through a modulation of inflammatory response. Arterioscler Thromb Vasc Biol. 2011

  • Albers CA, Cvejic A, Favier R, Bouwmans EE, Alessi MC, Bertone P, Jordan G, Kettleborough RN, Kiddle G, Kostadima M, Read RJ, Sipos B, Sivapalaratnam S, Smethurst PA, Stephens J, Voss K, Nurden A, Rendon A, Nurden P, Ouwehand WH. Exome sequencing identifies nbeal2 as the causative gene for gray platelet syndrome. Nat Genet. 2011;43:735-737

Selected 2017-2011 clinical publications

  • Roze H, Doassans-Cazaban G, Repusseau B, Ouattara A. Decrease of thoracopulmonary compliance with pressure assist controlled ventilation in ards patients under ecmo and transported to a referral centre. Intensive Care Med. 2016

  • Reant P, Metras A, Detaille D, Reynaud A, Diolez P, Jaspard B, Roudaut R, Ouattara A, Barandon L, Dos Santos P, Lafitte S. Impact of afterload increase on left ventricular myocardial deformation indices. J Am Soc Echocardiogr. 2016:1217-1228

  • Freynet A, Gobaille G, Joanes-Boyau O, Grandet P, Fleureau C, Ripoche J, Dewitte A, Ouattara A. Effects of chest physiotherapy by expiratory flow increase on secretion removal and lung mechanics in ventilated patients: A randomized crossover study. Intensive Care Med. 2016:1090-1091

  • Biais M, Lanchon R, Sesay M, Le Gall L, Pereira B, Futier E, Nouette-Gaulain K. Changes in stroke volume induced by lung recruitment maneuver predict fluid responsiveness in mechanically ventilated patients in the operating room. Anesthesiology. 2016

  • Tuffigo M, Lazaro E, James C, Subtil C, Viallard JF, Fiore M. Successful use of recombinant factor viia in a patient with acquired glanzmann thrombasthenia. Haemophilia. 2015;1:e116-e118

  • Roze H, Piquilloud L, Richard J, Jougon J, Dromer C, Mercat A, Ouattara A, Brochard L. Tidal volume during assisted ventilation after double-lung transplantation. Am J Respir Crit Care Med. 2015;192:637-639

  • Roze H, Germain A, Perrier V, Dewitte A, Joannes-Boyau O, Fleureau C, Ouattara A. Effect of flumazenil on diaphragm electrical activation during weaning from mechanical ventilation after acute respiratory distress syndrome. Br J Anaesth. 2015;114(2):269-275

  • Prévost A, Lafitte M, Pucheu Y, Couffinhal T. Education and home based training for intermittent claudication: Functional effects and quality of life. EUR J PREV CARDIOL. 2015;22:373-379

  • Lafitte M, Tastet S, Perez P, Serisé MA, Grandoulier AS, Aouizerate B, Sibon I, Capuron L, Couffinhal T. High sensitivity c reactive protein, fibrinogen levels and the onset of major depressive disorder in post-acute coronary syndrome. BMC Cardiovasc Disord. 2015;15

  • Dewitte A, Joannes-Boyau O, Sidobre C, Fleureau C, Bats ML, Derache P, Leuillet S, Ripoche J, Combe C, Ouattara A. Kinetic egfr and novel aki biomarkers to predict renal recovery. Clin J Am Soc Nephrol. 2015;10:1900-1910

  • Combes A, Bréchot N, Amour J, Cozic N, Lebreton G, Guidon C, Zogheib E, Thiranos J, Rigal J, Bastien O, Benhaoua H, Abry B, Ouattara A, Trouillet JL, Mallet A, Chastre J, Leprince P, Luyt CE. Early high-volume hemofiltration versus standard care for post-cardiac surgery shock. The heroics study. Am J Respir Crit Care Med. 2015;192:1179-1190

  • Biais M, Berthezène R, Petit L, Cottenceau V, Sztark F. Ability of escco to track changes in cardiac output. Br J Anaesth. 2015;115(3):403-410

  • Benhamou. Y, Baudel JL, Wynckel A, Galicier L, Azoulay E, Provôt F, Pène F, Mira JP, Presne C, Poullin P, Halimi JM, Riviere E, Kanouni T, Sequin A, Mousson C, Servais A, Bordessoule D, Perez P, Hamidou M, Chauveau D, Veyradier A, Coppo P. Are platelet transfusions harmful in acquired thrombotic thrombocytopenic purpura at the acute phase? Experience of the french thrombotic microangiopathies reference center. Am J Hematol. 2015;90(6):E127-129

  • Fiore M, James C, Mouton C, Calderon J, Barandon L, Ouattara A, Picard F. Assessment of platelet function with light transmission aggregometry in 24 patients supported with a continuous-flow left ventricular assist device: A single-center experience. J Thorac Cardiovasc Surg. 2014;S0022-5223(14)01071-X

  • Wittkop L, Bitard J, Lazaro E, Neau D, Bonnet F, Mercie P, Dupon M, Hessamfar M, Ventura M, Malvy D, Dabis F, Pellegrin JL, Moreau JF, Thiebaut R, Pellegrin I, Aquitaine GdÉCsSe. Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated hiv type 1-infected patients: The anrs co3 aquitaine cohort. J Infect Dis. 2013;207:622-627

  • Rozé H, Repusseau B, Perrier V, Germain A, Séramondi R, Dewitte A, Fleureau C, Ouattara A. Neuro-ventilatory efficiency during weaning from mechanical ventilation using neurally adjusted ventilatory assist. Br J Anaesth. 2013;111:955-960

  • Prevost A, Lafitte M, Pucheu Y, Couffinhal T. Education and home based training for intermittent claudication: Functional effects and quality of life. Eur J Prev Cardiol. 2013

  • Pham T, Combes A, Rozé H, Chevret S, Mercat A, Roch A, Mourvillier B, Ara-Somohano C, Bastien O, Zogheib E, Clavel M, Constan A, Marie Richard JC, Brun-Buisson C, Brochard L, Network RR. Extracorporeal membrane oxygenation for pandemic influenza a(h1n1)-induced acute respiratory distress syndrome: A cohort study and propensity-matched analysis. Am J Respir Crit Care Med. 2013;187:276-285

  • Legeron R, Xuereb F, Djabarouti S, Saux MC, Breilh D. Chemical stability of azacitidine suspensions for injection after cold-chain reconstitution of powder and storage. Am J Health Syst Pharm. 2013;70:2137-3142

  • Lafitte S, Pillois X, Reant P, Picard F, Arsac F, Dijos M, Coste P, Dos Santos P, Roudaut R. Estimation of pulmonary pressures and diagnosis of pulmonary hypertension by doppler echocardiography: A retrospective comparison of routine echocardiography and invasive hemodynamics. J Am Soc Echocardiogr. 2013;26:457-463

  • Lafitte M, Pucheu Y, Latry K, Dijos M, Casassus F, Couffinhal T. Predictors of cardiovascular prognosis in patients receiving optimized secondary prevention measures after acute coronary syndrome. Eur J Prev Cardiol. 2013;20:283-290

  • Laffite S, Reant P, Touche C, Pillois X, Dijos M, Arsac F, Peyrou J, Montaudon M, Ritter P, Roudaut R, Demaria A. Paradoxical response to exercise in asymptomatic hypertrophic cardiomyopathy: A new description of outflow tract obstruction dynamics. J am Coll Cardiol. 2013;62:842-850

  • Breilh D, Texier-Maugein J, Allaouchiche B, Saux MC, Boselli E. Carbapenems. J Chemother. 2013;25:1-17

  • Trancart S, Charreau I, Marchou B, Bocquentin M, Molina JM, Izopet J, Tangre P, Aboulker JP, Taburet AM, Group AS. Presence of lamivudine or emtricitabine is associated with reduced emergence of nonnucleoside reverse transcriptase inhibitor mutations in an efavirenz-based intermittent antiretroviral treatment regimen. Antimicrob Agents Chemother. 2012;56:1655-1657

  • Savel J, Lafitte M, Pucheu Y, Pradeau V, Tabarin A, Couffinhal T. Very low levels of hdl cholesterol and atherosclerosis, a variable relationship–a review of lcat deficiency. Vasc Health Risk Manag. 2012;8:357-361

  • Riedel M, Lafitte M, Pucheu Y, Latry K, Couffinhal T. Prognostic value of high-sensitivity c-reactive protein in a population of post-acute coronary syndrome patients receiving optimal medical treatment. Eur J Prev Cardiol. 2012;19:1128-1137

  • Reant P, Chasseriaud W, Pillois X, Dijos M, Arsac F, Roudaut R, Lafitte S. Early detection of left ventricular systolic dysfunction using two-dimensional speckle tracking strain evaluation in healthy subjects after acute alcohol intoxication. Echocardiography. 2012;29:927-932

  • Reant P, Barbot L, Touche C, Dijos M, Arsac F, Pillois X, Landelle M, Roudaut R, Lafitte S. Evaluation of global left ventricular systolic function using three-dimensional echocardiography speckle-tracking strain parameters. J Am Soc Echocardiogr. 2012;25:68-79

  • May MT, Hogg RS, Justice AC, Sheperd AC, Castogliola D, Ledergerber B, Thiebaut R, Gill MJ, Kirk O, Van Sighem A, Saag MS, Navarro G, Sobrino-Vegas P, Lampe F, Ingle S, Guest JL, Crane MH, D’Arminio Monforte A, Vehreschild JJ, Sterne JA, (ART-CC) ATCC. Heterogeneity in outcomes of treated hiv-positive patients in europe and north america: Relation with patient and cohort characteristics. Int J Epidemiol. 2012;41:1807-1820

  • Djabarouti S, Lazaro E, Breilh D, Pellegrin JL, Viallard JF. Lower 12-hour trough concentrations of mycophenolic acid in patients with active systemic vasculitides taking mycophenolate mofetil. J Rheumatol. 2012;39:2222-2223

  • Boselli E, Breilh D, Caillault-Sergent A, Djabarouti S, Guillaume C, Xuereb F, Bouvet L, Rimmelé T, Saux MC, Allaouchiche B. Alveolar diffusion and pharmacokinetics of linezolid administered in continuous infusion to critically ill patients with ventilator-associated pneumonia. J Antimicrob Chemother. 2012;67:1207-1210

  • Xuereb F, Chaignepain S, Breilh D, Godde F, Saux MC, Lenz C, Glueckmann M, Schmitter JM. Quantitative analysis of erythropoietin in human plasma by tandem mass spectrometry. Anal Bioanal Chem. 2011;400:2073-2084

  • Trouillet JL, Luyt CE, Guiguet M, Ouattara A, Vaissier E, Makri R, Nieszkowska A, Leprince P, Pavie A, Chastre J, Combes A. Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: A randomized trial. Ann Intern Med. 2011;154:373-383

  • Thambo JB, de Guillebon M, Dos Santos P, Xhaet O, Ploux S, Iriart X, Haissaguerre M, Bordachar P. Electrical dyssynchrony and resynchronization in tetralogy of fallot. Heart Rhythm. 2011;8(6):909-14. Epub

  • Roze H, Lafrikh A, Perrier V, Germain A, Dewitte A, Gomez F, Janvier G, Ouattara A. Daily titration of neurally adjusted ventilatory assist using the diaphragm electrical activity. Intensive Care Med. 2011;37:1087-1094

  • Roze H, Lafargue M, Ouattara A. Case scenario: Management of intraoperative hypoxemia during one-lung ventilation. Anesthesiology. 2011;114:167-174

  • Riedel M, Lafitte M, Pucheu Y, Latry K, Couffinhal T. Prognostic value of high-sensitivity c-reactive protein in a population of post-acute coronary syndrome patients receiving optimal medical treatment. Eur J Cardiovasc Prev Rehabil. 2011

  • Ploux S, Riviere A, Amraoui S, Whinnett Z, Barandon L, Lafitte S, Ritter P, Papaioannou G, Clementy J, Jais P, Bordenave L, Haissaguerre M, Bordachar P. Positron emission tomography in patients with suspected pacing system infections may play a critical role in difficult cases. Heart Rhythm. 2011;8:1478-1481

  • Pelletier J, Espinas J, Vu N, Norsic S, Baudouin A, Delevoye L, Trebosc J, Le Roux E, Santini C, Basset JM, Gauvin RM, Taoufik M. A well-defined silica-supported aluminium alkyl through an unprecedented, consecutive two-step protonolysis-alkyl transfer mechanism. Chem Commun (Camb). 2011;47:2979-2981

  • Mosnier-Thoumas S, Djabarouti S, Xuereb F, Lazaro E, Pellegrin JL, Saux MC, Breilh D. A sensitive liquid chromatography coupled with mass spectrometry method for the intracellular and plasma quantification of raltegravir after solid-phase extraction. J Pharm Pharmacol. 2011;63:1559-1565

  • Djabarouti S, Breilh D, Duffau P, Lazaro E, Greib C, Caubet O, Saux MC, Pellegrin JL, Viallard JF. Correction: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: An observational cohort study. Arthritis Res Ther. 2011;13:401

  • Biais M, Cottenceau V, Petit L, Masson F, Cochard JF, Sztark F. Impact of norepinephrine on the relationship between pleth variability index and pulse pressure variations in icu adult patients. Crit Care. 2011;15:R168