Thombosis and Myeloproliferative neoplasms
The pathogenic changes that occur in the blood and on the vessel wall resulting in thrombosis are not yet fully elucidated. Three major features, called the Virchow’s triad, are commonly said to contribute to thrombosis: rupture of the endothelial barrier (the most common cause being the rupture of atherosclerosic plaques), abnormal blood flow and hypercoagulability. In many patients with arterial or venous thrombosis, one of these parameters is indeed abnormal. Nevertheless, in a large number of cases (up to 50% in venous thrombosis), there is no explanation for the thrombotic event, which makes it difficult to evaluate the risk of recurrence and the type and duration of therapy.
Our project is aimed to better understand, diagnose and treat unexplained thrombosis. We aim to assess if EC are prothrombotic either because intrinsic defects modify the expression of their adhesive and anticoagulant molecules or because extrinsic factors such as blood cells or plasmatic components trigger responses such as inflammation does. We also focus on neutrophils, and more specifically on their ability to form Neutrophil Extracellular Traps, a type of neutrophil cell death that has been shown to promote arterial and venous thrombosis.