Marie-Ange Renault’s research focuses on characterizing cellular and molecular mechanisms that control blood vessel integrity in adults, with a particular attention devoted to the involvement of the Hedgehog signaling pathway. Her current working hypothesis is that impaired Hedgehog signaling observed in the setting of cardiovascular risk factors (including age and diabetes) induces endothelial dysfunction and participates in the development of vascular diseases. Her technical approaches mainly involve the use of transgenic mice (conditional KO mice), mouse models of angiogenesis and cell culture assays
2008/2011 Post-Doctoral training : Role and Mechanism of action of Hedgehog proteins in ischemia-induced angiogenesis and tissue repair. INSERM U1034, Cardiovascular adaptation to ischemia, Pessac, France (Director : Pr. Thierry Couffinhal).
2005/2008 Post-Doctoral training : Molecular mechanisms involved in Sonic Hedgehog-induced angiogenesis. Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, USA (Director : Dr Douglas W. Losordo).
2004 PhD - Biological and Medical Sciences in Biology-Health, Bordeaux 2 University, Bordeaux, France/Identification of transcription factors involved in the regulation of osteopontin expression. INSERM U441 Atherosclerosis, Pessac, France (Director : Pr. Jacques Bonnet).