Inserm U1034 - Biology of Cardiovascular Diseases

Clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. The endothelium is involved in the maintenance of normal organs and vascular structure and function. It may be thought as an organ by itself. Following its abnormalities in function would provide a tremendous opportunity to inform about the status of the disease progression. As it is widely distributed and easily accessible, it may be regarded as critical target in the fight against some cardio-neuro-vascular diseases.

Our project aims to improve endothelium knowledge, to understand how endothelium interacts with its microenvironment, to use it as a early marker of pathological conditions and to treat its dysfunction.

Wnt/Frizzled, Hedgehog and JAK2 signaling pathways are specifically studied in the endothelial dysfunction, in following different pathological settings:

  • Role of endothelial cells in thrombosis – example of myeloproliferative neoplasms
  • Role of endothelial dysfunction in heart failure with preserved ejection fraction
  • Role of endothelial dysfunction in critical hind limb ischemia
  • Endothelial cells, blood-brain barrier dysfunction in cerebrovascular disease
  • Retinopathy and vascular lesions

NEWS

PDZRN3 destabilizes endothelial cell-cell junctions through a PKCzeta-containing polarity complex to increase vascular permeability

Endothelial cells serve as a barrier between blood and tissues. Maintenance of the endothelial cell barrier depends on the integrity of intercellular junctions, which is regulated by a polarity complex that includes the zeta isoform of atypical protein kinase C...
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Expressed by Endothelial Cells Controls Blood Vessel Formation Through Wnt/β-Catenin Canonical Signaling.

Abstract OBJECTIVE: Vessel formation requires precise orchestration of a series of morphometric and molecular events controlled by a multitude of angiogenic factors and morphogens. Wnt/frizzled signaling is required for proper vascular formation. In this study, we...
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Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway.

Abstract Angiogenesis involves the coordinated growth and migration of endothelial cells (ECs) toward a proangiogenic signal. The Wnt planar cell polarity (PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morphogenesis...
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Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes.

Abstract AIMS: Microangiopathy, i.e. endothelial dysfunction, has long been suggested to contribute to the development of diabetic neuropathy, although this has never been fully verified. In the present paper, we have identified the role of Hedgehog (Hh) signalling in...
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Intrinsically impaired platelet production in some patients with persistent or chronic immune thrombocytopenia

Persistent or chronic immune thrombocytopenias (P/C-ITP) are acquired blood disorders lasting more than 3 months or 1 year, respectively. The pathogenesis of these disorders is thought to be immunological. We hypothesized that some patients with P/C-ITP might have an...
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Our laboratory

Inserm U1034
Centre National de la Recherche Scientifique
Adress : 1 Av. Magellan, 33600 Pessac
Phone : 05 57 89 19 79
Inserm U1034
Centre National de la Recherche Scientifique
Adress : 1 Av. Magellan, 33600 Pessac
Phone : 05 57 89 19 79

Our Partners

Region aquitaineRocheFondation Bettencourt SchuellerANRFondation recherche medicaleFondation de france