UMR-1034 Inserm
University of Bordeaux

Biology of Cardiovascular Diseases

works in close collaboration with

Clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. The endothelium is involved in the maintenance of normal organs and vascular structure and function. It may be thought as an organ by itself. Following its abnormalities in function would provide a tremendous opportunity to inform about the status of the disease progression. As it is widely distributed and easily accessible, it may be regarded as critical target in the fight against some cardio-neuro-vascular diseases. Our project aims to improve endothelium knowledge, to understand how endothelium interacts with its microenvironment, to use it as a early marker of pathological conditions and to treat its dysfunction. Wnt/Frizzled, Hedgehog and JAK2 signaling pathways are specifically studied in the endothelial dysfunction, in following different pathological settings:

  • Role of endothelial cells in thrombosis – example of myeloproliferative neoplasms
  • Role of endothelial dysfunction in heart failure with preserved ejection fraction
  • Role of endothelial dysfunction in critical hind limb ischemia
  • Endothelial cells, blood-brain barrier dysfunction in cerebrovascular disease
  • Retinopathy and vascular lesions

L’Unité 1034 récompensée pour ses travaux sur les maladies cardiovasculaires

 

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Latest publications

 

  • Duplaa, Cécile. Un facteur causal de l’insuffisance cardiaque – L’accumulation de liquide dans l’espace extracellulaire du myocarde. Med Sci. 21 mars 2023
  • Cornuault L, Rouault P, Duplàa C, Couffinhal T, Renault MA. Endothelial Dysfunction in Heart Failure With Preserved Ejection Fraction: What are the Experimental Proofs? Front Physiol. 8 juill 2022
  • Amatruda M, Chapouly C, Woo V, Safavi F, Zhang J, Dai D, et al. Astrocytic junctional adhesion molecule-A regulates T-cell entry past the glia limitans to promote central nervous system autoimmune attack. Brain Commun. 18 févr 2022
  • Rubin S, Bougaran P, Martin S, Abelanet A, Delobel V, Pernot M, et al. PHACTR-1 (Phosphatase and Actin Regulator 1) Deficiency in Either Endothelial or Smooth Muscle Cells Does Not Predispose Mice to Nonatherosclerotic Arteriopathies in 3 Transgenic Mice. Arterioscler Thromb Vasc Biol. mai 2022
  • Mishra A, Duplaà C, Vojinovic D, Suzuki H, Sargurupremraj M, Zilhão NR, et al. Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. Brain. 2 mai 2022
  • Abelanet A, Camoin M, Rubin S, Bougaran P, Delobel V, Pernot M, et al. Increased Capillary Permeability in Heart Induces Diastolic Dysfunction Independently of Inflammation, Fibrosis, or Cardiomyocyte Dysfunction. Arterioscler Thromb Vasc Biol. 5 mai 2022
  • Bats ML, Peghaire C, Delobel V, Dufourcq P, Couffinhal T, Duplàa C.Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity.Cold Spring Harb Perspect Med. 2022 Jan 24
  • Pernot M, Jaspard-Vinassa B, Abelanet A, Rubin S, Forfar I, Jeanningros S, Cetran L, Yu MH, Balse E, Hatem S, Dufourcq P, Couffinhal T, Duplàa C.Decrease of Pdzrn3 is required for heart maturation and protects against heart failure.Sci Rep. 2022 Jan 7
  • Mohammedi K, Abouleka Y, Carpentier C, Potier L, Dubois S, Foussard N, Rigalleau V, Gautier JF, Gourdy P, Charpentier G, Roussel R, Scheen A, Bauduceau B, Hadjadj S, Alhenc-Gelas F, Marre M, Velho Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes. Diabetes Care. 2022 Feb 1

 

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